Nature Communications (Sep 2018)
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
- Helmut Pein,
- Alexia Ville,
- Simona Pace,
- Veronika Temml,
- Ulrike Garscha,
- Martin Raasch,
- Khaled Alsabil,
- Guillaume Viault,
- Chau-Phi Dinh,
- David Guilet,
- Fabiana Troisi,
- Konstantin Neukirch,
- Stefanie König,
- Rosella Bilancia,
- Birgit Waltenberger,
- Hermann Stuppner,
- Maria Wallert,
- Stefan Lorkowski,
- Christina Weinigel,
- Silke Rummler,
- Marc Birringer,
- Fiorentina Roviezzo,
- Lidia Sautebin,
- Jean-Jacques Helesbeux,
- Denis Séraphin,
- Alexander S. Mosig,
- Daniela Schuster,
- Antonietta Rossi,
- Pascal Richomme,
- Oliver Werz,
- Andreas Koeberle
Affiliations
- Helmut Pein
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Alexia Ville
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Simona Pace
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Veronika Temml
- Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Ulrike Garscha
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Martin Raasch
- Institute of Biochemistry II and Center for Sepsis Control and Care, University Hospital Jena
- Khaled Alsabil
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Guillaume Viault
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Chau-Phi Dinh
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- David Guilet
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Fabiana Troisi
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Konstantin Neukirch
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Stefanie König
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Rosella Bilancia
- Department of Pharmacy, School of Medicine, University of Naples Federico II
- Birgit Waltenberger
- Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Hermann Stuppner
- Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Maria Wallert
- Chair of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich-Schiller-University Jena
- Stefan Lorkowski
- Chair of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich-Schiller-University Jena
- Christina Weinigel
- Institute of Transfusion Medicine, University Hospital Jena
- Silke Rummler
- Institute of Transfusion Medicine, University Hospital Jena
- Marc Birringer
- Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences
- Fiorentina Roviezzo
- Department of Pharmacy, School of Medicine, University of Naples Federico II
- Lidia Sautebin
- Department of Pharmacy, School of Medicine, University of Naples Federico II
- Jean-Jacques Helesbeux
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Denis Séraphin
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Alexander S. Mosig
- Institute of Biochemistry II and Center for Sepsis Control and Care, University Hospital Jena
- Daniela Schuster
- Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Antonietta Rossi
- Department of Pharmacy, School of Medicine, University of Naples Federico II
- Pascal Richomme
- Substances d’Origine Naturelle et Analogues Structuraux, SONAS, SFR4207 QUASAV, UNIV Angers, Université Bretagne Loire
- Oliver Werz
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Andreas Koeberle
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- DOI
- https://doi.org/10.1038/s41467-018-06158-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses.
