Communications Biology (Jan 2023)

ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells

  • Soichiro Suzuki,
  • Fumiaki Ando,
  • Sae Kitagawa,
  • Yu Hara,
  • Tamami Fujiki,
  • Shintaro Mandai,
  • Koichiro Susa,
  • Takayasu Mori,
  • Eisei Sohara,
  • Tatemitsu Rai,
  • Shinichi Uchida

DOI
https://doi.org/10.1038/s42003-023-04416-x
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 14

Abstract

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ZNF185 is identified as a novel PKA substrate and found to be important for the organization of endothelial cell–cell junctions and suppression of vascular hyperpermeability by regulating the cAMP/PKA/RhoA signaling pathway.