F1000Research (Nov 2023)

Case Report: Basaloid Squamous Cell Carcinoma of the Tongue: A Case Report [version 2; peer review: 2 approved]

  • Samiha Jameel Ahmed Khan,
  • Aayushi Pakhale,
  • Swati Patil,
  • Archana Sonone,
  • Alka Hande,
  • Madhuri Gawande

Journal volume & issue
Vol. 12

Abstract

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The upper aerodigestive tract is where basaloid squamous cell carcinoma (BSCC), a rare variation of conventional SCC, is most frequently found. The hypopharynx, tonsil, supraglottic larynx, tongue (base), and head-neck regions are particularly susceptible to BSCC. Clinically, the presentation of BSCC is similar to that of conventional SCC, but it has a poorer prognosis than conventional SCC. BSCC is distinguished histopathologically by a dimorphic pattern, a distinctive basal cell component paired with a squamous component, and a squamous component. However, its similar features to conventional SCC make it difficult to diagnose. Therefore, histopathology and immunohistochemistry play a crucial role in diagnosing such tumors. Here we present the case of a 70-year-old male diagnosed with BSCC involving the tongue.

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