Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report
Christoforos S. Kosmidis,
Chrysi Maria Mystakidou,
Georgios Koimtzis,
Evanthia Papadopoulou,
Vasiliki Theodorou,
Nikolaos Iason Katsios,
Eleni Georgakoudi,
Christina Sevva,
Ioannis Charalampous,
Nikolaos Varsamis,
Charilaos Koulouris,
Christina Michael,
Konstantinos Papadopoulos,
Georgios Anthimidis,
Sofia Baka
Affiliations
Christoforos S. Kosmidis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Chrysi Maria Mystakidou
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Georgios Koimtzis
Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK
Evanthia Papadopoulou
Shakolas Educational Centre for Clinical Medicine, University of Cyprus, Old Road Nicosia-Lemesos 215/6, 1678 Nicosia, Cyprus
Vasiliki Theodorou
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Nikolaos Iason Katsios
Medical School, Faculty of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Eleni Georgakoudi
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Christina Sevva
3rd Surgical Department, University General Hospital of Thessaloniki “AHEPA”, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece
Ioannis Charalampous
3rd Surgical Department, University General Hospital of Thessaloniki “AHEPA”, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece
Nikolaos Varsamis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Charilaos Koulouris
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Christina Michael
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Konstantinos Papadopoulos
3rd Surgical Department, University General Hospital of Thessaloniki “AHEPA”, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece
Georgios Anthimidis
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Sofia Baka
European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece
Castleman disease constitutes a rare class of lymphoproliferative disorders, with an estimated incidence of 21 to 25 per million patient years. The idiopathic subtype exhibits a significantly diverse clinical presentation, which can imitate many autoimmune, malignant, and infectious diseases. Cutaneous manifestations are uncommon and require in-depth investigation, especially when concurrent lymphadenopathy is present. A 79-year-old female, with a chronic, complicated erysipelas-like lesion, presented with bilaterally enlarged inguinal lymph nodes; after surgical excision, their histopathological examination revealed Castleman disease. Even though it is a benign condition, patients are often predisposed to developing certain types of malignancies, which can deteriorate their prognosis. An accurate and early diagnosis, along with effective treatment and prevention of recurrence, is of utmost importance in order to increase the patients’ overall survival and quality of life.
