Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands

• Waqas Rafique,
• Vasko Kramer,
• Tania Pardo,
• René Smits,
• Mona M. Spilhaug,
• Alexander Hoepping,
• Eduardo Savio,
• Henry Engler,
• Rodrigo Kuljs,
• Horacio Amaral,
• Patrick J. Riss

Affiliations

Waqas Rafique

Realomics SRI, Kjemisk Institutt, Universitetet i Oslo, Oslo, Norway

Vasko Kramer

Positronpharma SA, Providencia, Santiago, Chile

Tania Pardo

Departamento de Montevideo, Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay

René Smits

Advanced Biochemical Compounds GmbH, Radeberg, Germany

Mona M. Spilhaug

Realomics SRI, Kjemisk Institutt, Universitetet i Oslo, Oslo, Norway

Alexander Hoepping

Advanced Biochemical Compounds GmbH, Radeberg, Germany

Eduardo Savio

Departamento de Montevideo, Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay

Henry Engler

Departamento de Montevideo, Uruguayan Centre of Molecular Imaging (CUDIM), Montevideo, Uruguay

Rodrigo Kuljs

Zdrav Mozak Clinical Neuroscience Center, Providencia, Santiago, Chile

Horacio Amaral

Positronpharma SA, Providencia, Santiago, Chile

Patrick J. Riss

Realomics SRI, Kjemisk Institutt, Universitetet i Oslo, Oslo, Norway