Advanced strategies of scaffolds design for bone regeneration
Jian Song,
Longfei Li,
Lei Fang,
Enshuo Zhang,
Yu Zhang,
Zhuxuan Zhang,
Pranav Vangari,
Yaqin Huang,
Feng Tian,
Yu Zhao,
Wei Chen,
Jiajia Xue
Affiliations
Jian Song
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Longfei Li
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Lei Fang
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Enshuo Zhang
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Yu Zhang
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Zhuxuan Zhang
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Pranav Vangari
Department of Physics University of Texas at Arlington Arlington Texas USA
Yaqin Huang
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Feng Tian
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Yu Zhao
Department of Orthopaedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China
Wei Chen
Department of Physics University of Texas at Arlington Arlington Texas USA
Jiajia Xue
Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects. In this review article, we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair, especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli. We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment. Finally, we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds, aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.
