Communications Biology (Sep 2022)
Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo
- Jessica M. Miller,
- Moustafa H. Meki,
- Ahmed Elnakib,
- Qinghui Ou,
- Riham R. E. Abouleisa,
- Xian-Liang Tang,
- Abou Bakr M. Salama,
- Ahmad Gebreil,
- Cindy Lin,
- Hisham Abdeltawab,
- Fahmi Khalifa,
- Bradford G. Hill,
- Najah Abi-Gerges,
- Roberto Bolli,
- Ayman S. El-Baz,
- Guruprasad A. Giridharan,
- Tamer M. A. Mohamed
Affiliations
- Jessica M. Miller
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Moustafa H. Meki
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Ahmed Elnakib
- Department of Bioengineering, University of Louisville
- Qinghui Ou
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Riham R. E. Abouleisa
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Xian-Liang Tang
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Abou Bakr M. Salama
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Ahmad Gebreil
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Cindy Lin
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Hisham Abdeltawab
- Department of Bioengineering, University of Louisville
- Fahmi Khalifa
- Department of Bioengineering, University of Louisville
- Bradford G. Hill
- Envirome Institute, Diabetes and Obesity Center, Department of Medicine, University of Louisville
- Najah Abi-Gerges
- AnaBios Corporation
- Roberto Bolli
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- Ayman S. El-Baz
- Department of Bioengineering, University of Louisville
- Guruprasad A. Giridharan
- Department of Bioengineering, University of Louisville
- Tamer M. A. Mohamed
- From the Institute of Molecular Cardiology, Department of Medicine, University of Louisville
- DOI
- https://doi.org/10.1038/s42003-022-03919-3
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
A physiological culture system to electro-mechanically stimulate pig heart slices to assess the drug effects on the functionality, metabolic activity, and structural integrity of the heart tissue under physiological and hypertrophic condition.
