Frontiers in Cellular and Infection Microbiology (Dec 2021)

Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects

  • Jiaqi Zhang,
  • Jiaqi Zhang,
  • Shan Xing,
  • Dan Liang,
  • Wei Hu,
  • Changwen Ke,
  • Jinyong He,
  • Runyu Yuan,
  • Yile Huang,
  • Yizhe Li,
  • Dongdong Liu,
  • Xuedong Zhang,
  • Lin Li,
  • Jianhua Lin,
  • Weili Li,
  • Xiangyun Teng,
  • Yijun Liu,
  • Wei Wen,
  • Qiang Kang,
  • Dawei Wang,
  • Wanli Liu,
  • Jianhua Xu

DOI
https://doi.org/10.3389/fcimb.2021.791660
Journal volume & issue
Vol. 11

Abstract

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The appearance and magnitude of the immune response and the related factors correlated with SARS-CoV-2 vaccination need to be defined. Here, we enrolled a prospective cohort of 52 participants who received two doses of inactivated vaccines (BBIBP-CorV). Their serial plasma samples (n = 260) over 2 months were collected at five timepoints. We measured antibody responses (NAb, S-IgG and S-IgM) and routine blood parameter. NAb seroconversion occurred in 90.7% of vaccinated individuals and four typical NAb kinetic curves were observed. All of the participants who seroconverted after the first dose were females and had relatively high prevaccine estradiol levels. Moreover, those without seroconversion tended to have lower lymphocyte counts and higher serum SAA levels than those who experienced seroconversion. The NAb titers in young vaccine recipients had a significantly higher peak than those in elderly recipients. S-IgG and S-IgM dynamics were accompanied by similar trends in NAb. Here, we gained insight into the dynamic changes in NAbs and preliminarily explored the prevaccine blood parameters related to the kinetic subclasses, providing a reference for vaccination strategies.

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