Frontiers in Neuroscience (Jul 2017)
Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception
- Indira García-Cordero,
- Indira García-Cordero,
- Sol Esteves,
- Ezequiel P. Mikulan,
- Ezequiel P. Mikulan,
- Eugenia Hesse,
- Eugenia Hesse,
- Eugenia Hesse,
- Fabricio H. Baglivo,
- Fabricio H. Baglivo,
- Walter Silva,
- María del Carmen García,
- Esteban Vaucheret,
- Carlos Ciraolo,
- Hernando S. García,
- Hernando S. García,
- Hernando S. García,
- Federico Adolfi,
- Federico Adolfi,
- Marcos Pietto,
- Marcos Pietto,
- Eduar Herrera,
- Eduar Herrera,
- Agustina Legaz,
- Facundo Manes,
- Facundo Manes,
- Facundo Manes,
- Adolfo M. García,
- Adolfo M. García,
- Adolfo M. García,
- Mariano Sigman,
- Mariano Sigman,
- Tristán A. Bekinschtein,
- Tristán A. Bekinschtein,
- Agustín Ibáñez,
- Agustín Ibáñez,
- Agustín Ibáñez,
- Agustín Ibáñez,
- Agustín Ibáñez,
- Lucas Sedeño,
- Lucas Sedeño
Affiliations
- Indira García-Cordero
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Indira García-Cordero
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Sol Esteves
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Ezequiel P. Mikulan
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Ezequiel P. Mikulan
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Eugenia Hesse
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Eugenia Hesse
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Eugenia Hesse
- Instituto de Ingeniería Biomédica, Facultad de Ingeniería, Universidad de Buenos AiresBuenos Aires, Argentina
- Fabricio H. Baglivo
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Fabricio H. Baglivo
- Instituto de Ingeniería Biomédica, Facultad de Ingeniería, Universidad de Buenos AiresBuenos Aires, Argentina
- Walter Silva
- Programa de Cirugía de Epilepsia, Hospital Italiano de Buenos AiresBuenos Aires, Argentina
- María del Carmen García
- Programa de Cirugía de Epilepsia, Hospital Italiano de Buenos AiresBuenos Aires, Argentina
- Esteban Vaucheret
- Programa de Cirugía de Epilepsia, Hospital Italiano de Buenos AiresBuenos Aires, Argentina
- Carlos Ciraolo
- Programa de Cirugía de Epilepsia, Hospital Italiano de Buenos AiresBuenos Aires, Argentina
- Hernando S. García
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Hernando S. García
- Pontificia Universidad JaverianaBogotá, Colombia
- Hernando S. García
- Centro de Memoria y Cognición IntellectusBogotá, Colombia
- Federico Adolfi
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Federico Adolfi
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Marcos Pietto
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Marcos Pietto
- Unit of Applied Neurobiology, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Consejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires, Argentina
- Eduar Herrera
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Eduar Herrera
- Departamento de Estudios Psicológicos, Universidad ICESICali, Colombia
- Agustina Legaz
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Facundo Manes
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Facundo Manes
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Facundo Manes
- Australian Research Council, Centre of Excellence in Cognition and its Disorders, Macquarie UniversitySydney, NSW, Australia
- Adolfo M. García
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Adolfo M. García
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Adolfo M. García
- 0Faculty of Education, National University of CuyoMendoza, Argentina
- Mariano Sigman
- 1Laboratory of Neuroscience, Universidad Torcuato Di TellaBuenos Aires, Argentina
- Mariano Sigman
- 2Departamento de Fısica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Fısica de Buenos Aires, Consejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires, Argentina
- Tristán A. Bekinschtein
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Tristán A. Bekinschtein
- 3Department of Psychology, University of CambridgeCambridge, United Kingdom
- Agustín Ibáñez
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Agustín Ibáñez
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- Agustín Ibáñez
- Australian Research Council, Centre of Excellence in Cognition and its Disorders, Macquarie UniversitySydney, NSW, Australia
- Agustín Ibáñez
- 4Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo IbáñezSantiago, Chile
- Agustín Ibáñez
- 5Universidad Autónoma del CaribeBarranquilla, Colombia
- Lucas Sedeño
- Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro UniversityBuenos Aires, Argentina
- Lucas Sedeño
- National Scientific and Technical Research CouncilBuenos Aires, Argentina
- DOI
- https://doi.org/10.3389/fnins.2017.00411
- Journal volume & issue
-
Vol. 11
Abstract
Interoception, the monitoring of visceral signals, is often presumed to engage attentional mechanisms specifically devoted to inner bodily sensing. In fact, most standardized interoceptive tasks require directing attention to internal signals. However, most studies in the field have failed to compare attentional modulations between internally- and externally-driven processes, thus probing blind to the specificity of the former. Here we address this issue through a multidimensional approach combining behavioral measures, analyses of event-related potentials and functional connectivity via high-density electroencephalography, and intracranial recordings. In Study 1, 50 healthy volunteers performed a heartbeat detection task as we recorded modulations of the heartbeat-evoked potential (HEP) in three conditions: exteroception, basal interoception (also termed interoceptive accuracy), and post-feedback interoception (sometimes called interoceptive learning). In Study 2, to evaluate whether key interoceptive areas (posterior insula, inferior frontal gyrus, amygdala, and somatosensory cortex) were differentially modulated by externally- and internally-driven processes, we analyzed human intracranial recordings with depth electrodes in these regions. This unique technique provides a very fine grained spatio-temporal resolution compared to other techniques, such as EEG or fMRI. We found that both interoceptive conditions in Study 1 yielded greater HEP amplitudes than the exteroceptive one. In addition, connectivity analysis showed that post-feedback interoception, relative to basal interoception, involved enhanced long-distance connections linking frontal and posterior regions. Moreover, results from Study 2 showed a differentiation between oscillations during basal interoception (broadband: 35–110 Hz) and exteroception (1–35 Hz) in the insula, the amygdala, the somatosensory cortex, and the inferior frontal gyrus. In sum, this work provides convergent evidence for the specificity and dynamics of attentional mechanisms involved in interoception.
Keywords