HUBUNGAN ANTARA ASUPAN KAPSUL IODIUM DAN KEJADIAN AUTOIMMUNE THYROID DISEASE (AITD)

Abstract

Iodine is the main component in the synthesis of thyroid hormones. Therefore,adequate iodine consumption is important for thyroid hormone production. Iodineinterference with TSH system can be as the limiting factor for thyroid hormonesproduction. Magelang district knows as IDD area had program to supply intakeiodine from iodine capsule and iodinated salt. In endemic Iodine Deficiencydisorders (IDD) area, intake iodine was taken from iodine capsule and iodinatedsalt. Iodine stored at thyroglobulin. Post-translational modification of thyroglobulinby iodine has immunological consequences such that increased AutoimmuneThyroid Disease (AITD). Tiroglobulin and Thyroidperoxidase antibodies arethe main factor of production of AITD. A study was to asses the descriptionbetween iodine intake and tiroglobulin and thyroidperoxidase antibodies causedAITD. The study was conducted at Magelang district and the respondents arechildbearing age woman. Samples were collected to measured TPO antibody andThyroglobulin antibody. Magelang district is one of the IDD areas received capsuleiodine distributed to prevent new IDD cases. Most all of respondent consumediodine capsule 1-2 capsule/year. The result showed that all respondent haveTPO and Thyroglobulin antibodies. 23% respondent has positive thyroglobulinand 47% positive TPO antibody. Statistical analysis showed that Iodine capsuleintake is one of predesposition factor of AITD. The results showed that intake ofhigh concentration iodine capsule had immunological consequences. Over doseof iodine can increased incident of AITD. Thyroglobulin and TPO antibodies thatfound in all respondents with consume high concentration iodine capsule.

Keywords

• Iodine capsule, Iodine salt, TPO antibody, Thyroglobulin antibody, AITD.