Nature Communications (Jun 2016)
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
- Henrik Lilljebjörn,
- Rasmus Henningsson,
- Axel Hyrenius-Wittsten,
- Linda Olsson,
- Christina Orsmark-Pietras,
- Sofia von Palffy,
- Maria Askmyr,
- Marianne Rissler,
- Martin Schrappe,
- Gunnar Cario,
- Anders Castor,
- Cornelis J. H. Pronk,
- Mikael Behrendtz,
- Felix Mitelman,
- Bertil Johansson,
- Kajsa Paulsson,
- Anna K. Andersson,
- Magnus Fontes,
- Thoas Fioretos
Affiliations
- Henrik Lilljebjörn
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Rasmus Henningsson
- Centre for Mathematical Sciences, Lund University
- Axel Hyrenius-Wittsten
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Linda Olsson
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Christina Orsmark-Pietras
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Sofia von Palffy
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Maria Askmyr
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Marianne Rissler
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Martin Schrappe
- Department of Pediatrics, University Hospital Schleswig-Holstein
- Gunnar Cario
- Department of Pediatrics, University Hospital Schleswig-Holstein
- Anders Castor
- Department of Pediatrics, Skåne University Hospital, Lund University
- Cornelis J. H. Pronk
- Department of Pediatrics, Skåne University Hospital, Lund University
- Mikael Behrendtz
- Department of Pediatrics, Linköping University Hospital
- Felix Mitelman
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Bertil Johansson
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Kajsa Paulsson
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Anna K. Andersson
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- Magnus Fontes
- Centre for Mathematical Sciences, Lund University
- Thoas Fioretos
- Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
- DOI
- https://doi.org/10.1038/ncomms11790
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The fusion of two genes during the pathogenesis of cancer can create oncogenes. In this study, the authors screen pediatric B-cell precursor acute lymphoblastic leukaemia samples for the presence of fusion genes and describe fusion genes that define new molecular subtypes of the disease
