PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

Feng Dong; Qian Li; Chao Yang; Dawei Huo; Xing Wang; Chunbo Ai; Yu Kong; Xiaoyu Sun; Wen Wang; Yan Zhou; Xing Liu; Wei Li; Weiwei Gao; Wen Liu; Chunsheng Kang; Xudong Wu

doi:10.1038/s41467-018-06968-7

Nature Communications (Oct 2018)

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

Feng Dong,
Qian Li,
Chao Yang,
Dawei Huo,
Xing Wang,
Chunbo Ai,
Yu Kong,
Xiaoyu Sun,
Wen Wang,
Yan Zhou,
Xing Liu,
Wei Li,
Weiwei Gao,
Wen Liu,
Chunsheng Kang,
Xudong Wu

Affiliations

Feng Dong: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Qian Li: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Chao Yang: Department of Neurosurgery, Tianjin Medical University General Hospital
Dawei Huo: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Xing Wang: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Chunbo Ai: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Yu Kong: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Xiaoyu Sun: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics
Wen Wang: Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
Yan Zhou: Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
Xing Liu: Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, 6 Tiantanxi Li
Wei Li: Department of Pathology, Tianjin Nankai Hospital
Weiwei Gao: School of Pharmaceutical Sciences, Xiamen University, Xiamen
Wen Liu: School of Pharmaceutical Sciences, Xiamen University, Xiamen
Chunsheng Kang: Department of Neurosurgery, Tianjin Medical University General Hospital
Xudong Wu: Department of Cell Biology, Tianjin Medical University, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics

DOI: https://doi.org/10.1038/s41467-018-06968-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expression programs, at least partly dependent on its H3R8me2a activity, in GBM pathogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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