EnABLing Cathepsin-Driven Melanoma Metastasis

Abstract

Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

Keywords

• cathepsin
• abl1
• abl2
• abl
• arg
• ets1
• sp1
• nf-κb
• rela
• cysteine cathepsins