Vestnik Transplantologii i Iskusstvennyh Organov (May 2009)

THE EXPERIENCE OF IMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMIOCARDIAL BIOPSIES FOR THE DIAGNOSIS OF THE HUMORAL REJECTION IN THE PATIENTS WITH HEART ALLOGRAFT

  • A. G. Kupriyanova,
  • L. V. Beletskaya,
  • V. A. Zaydenov,
  • A. Y. Kormer,
  • E. N. Kazakov,
  • A. M. Golts,
  • V. V. Chestukhin,
  • I. M. Iljinsky,
  • E. I. Ryaboschtanova

DOI
https://doi.org/10.15825/1995-1191-2009-3-30-36
Journal volume & issue
Vol. 11, no. 3
pp. 30 – 36

Abstract

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The aim of present study was to characterize immunohistological features of humoral (antibody-mediated rejection, AMR) by evaluating their manifestation, localization and distribution in endomiocardial biopsies (EMBs) from patients after heart transplantation. The role of AMR in the development of allograft vasculopathy is investigated widely. The examine of more than 1000 EMBs maid it possible to elaborate the diagnostic criteria of acute humoral rejection, to characterize immunomorfological peculiarities of long-term heart allograft and demonstrated the relation AMR with the early development of coronary artery diseases.

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