Pharmaceutics (Nov 2022)

Development of Guar Gum-Pectin-Based Colon Targeted Solid Self-Nanoemulsifying Drug Delivery System of Xanthohumol

  • Mahesh Hanmantrao,
  • Sourabh Chaterjee,
  • Rajan Kumar,
  • Sukriti Vishwas,
  • Vancha Harish,
  • Omji Porwal,
  • Mohammed Alrouji,
  • Othman Alomeir,
  • Sharif Alhajlah,
  • Monica Gulati,
  • Gaurav Gupta,
  • Kamal Dua,
  • Sachin Kumar Singh

DOI
https://doi.org/10.3390/pharmaceutics14112384
Journal volume & issue
Vol. 14, no. 11
p. 2384

Abstract

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Present study deciphers development of oral polysaccharide-based colon targeted solid self-nanoemulsifying drug delivery system (S-SNEDDS) of xanthohumol (XH). Several studies have shown that XH has anti-inflammatory and antioxidant properties, suggesting that it could be a good candidate for the treatment of colorectal diseases (CRD). Despite its potential, XH has a low aqueous solubility. As a result, its bioavailability is constrained by the dissolution rate. The liquid (L)-SNEDDS was constituted using Labrafac PG as oil, Tween 80 as surfactant and Transcutol P as co-surfactant. The L-SNEDDS was then adsorbed onto the surface of guar gum and pectin and developed into S-SNEDDS powder. Ternary phase diagram was used to optimize the process of developing L-SNEDDS. The formulation showed mean droplet size of 118.96 ± 5.94 nm and zeta potential of −19.08 ± 0.95 mV and drug loading of 94.20 ± 4.71%. Dissolution studies carried out in medium containing rat caecal contents (RCC) represented the targeted release of S-SNEDDS powder. It was observed that S-SNEDDS showed less than 10% release XH in initial 5 h and rapid release occurred between the 5th and 10th hour. Results of cytotoxicity studies revealed good cytotoxicity of XH loaded S-SNEDDS for Caco2 cells as compared to raw-XH.

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