Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers

Guihua Cui; Guihua Cui; Hao Wang; Shengsen Long; Tianshuo Zhang; Xiaoyu Guo; Shuiying Chen; Toyoji Kakuchi; Qian Duan; Donghai Zhao

doi:10.3389/fbioe.2022.931830

Frontiers in Bioengineering and Biotechnology (Jul 2022)

Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers

Guihua Cui,
Guihua Cui,
Hao Wang,
Shengsen Long,
Tianshuo Zhang,
Xiaoyu Guo,
Shuiying Chen,
Toyoji Kakuchi,
Qian Duan,
Donghai Zhao

Affiliations

Guihua Cui: Science and Technology Division, Jilin Medical University, Jilin, China
Guihua Cui: Department of Materials Science and Engineering, Changchun University of Science and Technology, Jilin, China
Hao Wang: Science and Technology Division, Jilin Medical University, Jilin, China
Shengsen Long: Science and Technology Division, Jilin Medical University, Jilin, China
Tianshuo Zhang: Science and Technology Division, Jilin Medical University, Jilin, China
Xiaoyu Guo: Jilin Vocational College of Industry and Technology, Jilin, China
Shuiying Chen: Department of Materials Science and Engineering, Changchun University of Science and Technology, Jilin, China
Toyoji Kakuchi: Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Japan
Qian Duan: Department of Materials Science and Engineering, Changchun University of Science and Technology, Jilin, China
Donghai Zhao: Science and Technology Division, Jilin Medical University, Jilin, China

DOI: https://doi.org/10.3389/fbioe.2022.931830
Journal volume & issue: Vol. 10

Abstract

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A series of thermo- and light-responsive copolymers of poly (N-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized via reversible addition–fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06–1.24, in which Mn changed regularly with the monomer concentration. Subsequently, the diblock copolymers were successfully modified on the surface of iron oxide nanoparticles through the interaction between the chemical bonds to prepare Fe3O4@(PNIPAM-b-PAzoMA) nanoparticles. The size of fabricated nanoparticles with excellent thermo-sensitivity and photo-sensitivity was controlled at about 40–50 nm. Cell viability assays suggested that the nanoparticles showed no significant cytotoxicity and potential drug delivery in the tumor microenvironment.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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