Applying Thermodynamics, Enzyme Kinetics, and pH in Medical Biochemistry - A Team-Based Learning Exercise

Abstract

Abstract This is a team-based learning (TBL) exercise used to review concepts and apply knowledge in thermodynamics, enzyme kinetics, and pH in a medical biochemistry course. It can be presented to classes on a course server or as a PowerPoint presentation. The goal of the resource is to assess the student's ability to recall facts and concepts concerning thermodynamics, enzyme kinetics, and pH and challenge students to apply and integrate the information they have learned in a TBL environment. A standard TBL format is used. The resource includes 10 individual readiness assurance test (IRAT)/group readiness assurance test (GRAT) multiple-choice questions which focus on concepts and facts in thermodynamics, enzyme kinetics, and pH, and nine questions in which the students must be able to apply that knowledge to solve the problem. The GRAT works well with IF-AT cards, but the application generates the best intra-team and inter-team discussions if completed one question at a time. This TBL exercise has been used for 4 years at the Indiana University School of Medicine South Bend and modified to its present form. It has been well-received and evaluated by the students each year as a very useful TBL exercise that promoted their ability to apply the concepts of thermodynamics, enzyme kinetics, and pH to solve significant problems. The TBL format also promotes the communication and professionalism competencies.

Keywords

• TBL
• Team-based Learning
• Competitive Inhibition
• Enzyme Kinetics
• pH
• Cooperativity