Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

A. Saggini; D. Tripodi; G. Maccauro; M.L. Castellani; A. Anogeianaki; S. Teté; P. Felaco; M.A. De Luths; R. Galzio; M. Fulcheri; T.C. Theoharides; A. Caraffa; P. Antinolfi; M. Felaco; F. Conti; G. Neri; F. Pandolfi; E. Tomato; Y.B. Shaik-Dasthagirisaheb

doi:10.1177/1721727X1100900103

European Journal of Inflammation (Jan 2011)

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

A. Saggini,
D. Tripodi,
G. Maccauro,
M.L. Castellani,
A. Anogeianaki,
S. Teté,
P. Felaco,
M.A. De Luths,
R. Galzio,
M. Fulcheri,
T.C. Theoharides,
A. Caraffa,
P. Antinolfi,
M. Felaco,
F. Conti,
G. Neri,
F. Pandolfi,
E. Tomato,
Y.B. Shaik-Dasthagirisaheb

Affiliations

A. Saggini: Bastian Lab, MSKCC, New York, USA
D. Tripodi: School of Dentistry, University of Chieti, Italy
G. Maccauro: Department of Orthopaedics, Catholic University of Rome, Italy
M.L. Castellani: Immunology Division, University of Chieti, Chieti, Italy
A. Anogeianaki: Physiology Department, School of Medicine, Aristotle University of Thessaloniki, Greece
S. Teté: School of Dentistry, University of Chieti, Italy
P. Felaco: Department of Human Dynamics, University of Chieti, Italy
M.A. De Luths: Department of Human Dynamics, University of Chieti, Italy
R. Galzio: Department of Health Sciences, University of L'Aquila, Italy
M. Fulcheri: Department of Clinical Psychology, University of Chieti, Italy
T.C. Theoharides: Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA, USA
A. Caraffa: Orthopaedics Division, University of Perugia, Perugia, Italy
P. Antinolfi: Orthopaedics Division, University of Perugia, Perugia, Italy
M. Felaco: Department of Human Dynamics, University of Chieti, Italy
F. Conti: Orthopaedics Division, University of Perugia, Perugia, Italy
G. Neri: Institute of Internal Medicine, University of Chieti, Italy
F. Pandolfi: Institute of Internal Medicine, Catholic University, Rome, Italy
E. Tomato: Department of Oncology and Experimental Medicine, University of Chieti, Chieti, Italy
Y.B. Shaik-Dasthagirisaheb: Department of Medicine, Boston University School of Medicine, Boston, MA, USA

DOI: https://doi.org/10.1177/1721727X1100900103
Journal volume & issue: Vol. 9

Abstract

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Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNFα in their cytoplasmatic granules and release upon activation. TNF-alpha is a potent multifunctional cytokine involved in autoimmune diseases, cancer, allergy, and acute and chronic inflammation. In this study, we revisit the interrelationship between TNFα and mast cells.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

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