Nature Communications (May 2018)

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

  • Julien Bricambert,
  • Marie-Clotilde Alves-Guerra,
  • Pauline Esteves,
  • Carina Prip-Buus,
  • Justine Bertrand-Michel,
  • Hervé Guillou,
  • Christopher J. Chang,
  • Mark N. Vander Wal,
  • François Canonne-Hergaux,
  • Philippe Mathurin,
  • Violeta Raverdy,
  • François Pattou,
  • Jean Girard,
  • Catherine Postic,
  • Renaud Dentin

DOI
https://doi.org/10.1038/s41467-018-04361-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 18

Abstract

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Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.