Nature Communications (May 2018)
The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
Abstract
Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation.