Application of Laboratory Animal Models in Cancer Precision Medicine Research

Abstract

Laboratory animal disease models play an important role in clinical translational research, and have been widely used in life sciences, medical chemistry, and biological health. In addition, animal models are often used as effective tools to study cancer occurrence, development, and metastasis. In recent years, with the increasing demand for precision medicine, the patient-derived tumor xenograft (PDX) model has been widely used as an important model for drug screening and translational research in the development of anti-cancer drugs and the introduction of personalized treatment plans for individuals. With the perspective of the development of experimental animal tumor models and the application of immunodeficient animals, this review summarizes the status of PDX models in precision medicine, defines the characteristics of different types of animal models, and provides prospects for future development trends and applications.

Keywords

• laboratory animal
• patient-derived tumor xenograft model
• precision medicine
• human-derived mice