The features of pathophisiology Helicobacter pilory associated ulceractive disease from the Khakasses

Abstract

Peculiarities of pathogene sis of Helicobacter pylori (HP)-associated gastric ulcer (GU) in Khakas se s are investigated. It is found that, in con - trast to Caucasian s, the activation of the Т-cell and humoral parts of the immune response in Mongoloids with GU is accompanied by the high con - tent of CD4 +- and CD20 +-lympho cytes in the muscou s coat of stomach. Changes revealed in the peripheral blood in GU patients were character - ized by a decrease in the magnitude of CD4 +- and CD8 +-lympho cyte subpopulations compared to patients with chronic gastritis. The detected pos - itive correlation between the АА-251 genotype of interleukin-8 and the risk of GU development in Khakssses indicated in favor of the existence of immuno-genetic regularities of GU development. The reasonability of determining population risk and protective genotypes of development of HРassociated GU in Khakasses is discussed.

Keywords

• helicobacter pylori
• язвенная болезнь
• хакасы
• th1/th2-иммунный ответ
• аллельный полиморфизм генов
• интерлейкин-8