Nature Communications (Jul 2020)

Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

  • Daniel Trnka,
  • Anna D. Engelke,
  • Manuela Gellert,
  • Anna Moseler,
  • Md Faruq Hossain,
  • Tobias T. Lindenberg,
  • Luca Pedroletti,
  • Benjamin Odermatt,
  • João V. de Souza,
  • Agnieszka K. Bronowska,
  • Tobias P. Dick,
  • Uli Mühlenhoff,
  • Andreas J. Meyer,
  • Carsten Berndt,
  • Christopher Horst Lillig

DOI
https://doi.org/10.1038/s41467-020-17323-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Glutaredoxins are a family of essential enzymes divided into two major classes with either a CGFS or a CxxC active site, of which only the latter exhibits oxidoreductase activity. Here the authors address the structural basis for the functional difference between the two classes of glutaredoxins.