Nature Communications (Apr 2019)

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

  • Minjun Yang,
  • Mattias Vesterlund,
  • Ioannis Siavelis,
  • Larissa H. Moura-Castro,
  • Anders Castor,
  • Thoas Fioretos,
  • Rozbeh Jafari,
  • Henrik Lilljebjörn,
  • Duncan T. Odom,
  • Linda Olsson,
  • Naveen Ravi,
  • Eleanor L. Woodward,
  • Louise Harewood,
  • Janne Lehtiö,
  • Kajsa Paulsson

DOI
https://doi.org/10.1038/s41467-019-09469-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low in hyperdiploid cases and transcriptional dysregulation in relation to topologically associating domain borders in some of these cases.