Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases

Hsiu-Jung Liao; Yi-Ping Yang; Yu-Hao Liu; Huan-Chin Tseng; Teh-Ia Huo; Shih-Hwa Chiou; Chih-Hung Chang

Regenerative Therapy (Jun 2024)

Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases

Hsiu-Jung Liao,
Yi-Ping Yang,
Yu-Hao Liu,
Huan-Chin Tseng,
Teh-Ia Huo,
Shih-Hwa Chiou,
Chih-Hung Chang

Affiliations

Hsiu-Jung Liao: Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
Yi-Ping Yang: Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Yu-Hao Liu: Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan
Huan-Chin Tseng: Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
Teh-Ia Huo: Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Shih-Hwa Chiou: Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Department of Medical Research, Taipei Veterans General Hospital, No. 201, Section. 2, Shipai Rd, Beitou District, Taipei City, 11217, Taiwan.
Chih-Hung Chang: Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan City, Taiwan; Corresponding author. Department of Orthopedic Surgery, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya S. Road, Banqiao District, New Taipei City, 220216, Taiwan.

Journal volume & issue: Vol. 26
pp. 599 – 610

Abstract

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Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and release extracellular vesicles (EVs), which subsequently influence the biological activities of recipient cells. Recently, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown the potential to modulate various physiological and pathological processes through the modulation of cellular differentiation, immune responses, and tissue repair. This review explores the roles and therapeutic potential of MSC-EVs in OA and rheumatoid arthritis, cardiovascular disease, age-related macular degeneration, Alzheimer's disease, and other degenerative diseases. Notably, we provide a comprehensive summary of exosome biogenesis, microRNA composition, mechanisms of intercellular transfer, and their evolving role in the highlight of exosome-based treatments in both preclinical and clinical avenues.

Published in Regenerative Therapy

ISSN: 2352-3204 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Cytology
Website: http://www.journals.elsevier.com/regenerative-therapy/

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