Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Chuan-Sheng Lin; Chih-Jung Chang; Chia-Chen Lu; Jan Martel; David M Ojcius; Yun-Fei Ko; John D Young; Hsin-Chih Lai

doi:10.4103/2319-4170.138314

Biomedical Journal (Oct 2014)

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Chuan-Sheng Lin,
Chih-Jung Chang,
Chia-Chen Lu,
Jan Martel,
David M Ojcius,
Yun-Fei Ko,
John D Young,
Hsin-Chih Lai

Affiliations

Chuan-Sheng Lin: Center for Molecular and Clinical Immunology; Department of Medical Biotechnology and Laboratory Sciences, College of Medicine; Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan
Chih-Jung Chang: Center for Molecular and Clinical Immunology; Department of Medical Biotechnology and Laboratory Sciences, College of Medicine; Department of Microbiology and Immunology; Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan
Chia-Chen Lu: Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan
Jan Martel: Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan
David M Ojcius: Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced, Merced, California, USA
Yun-Fei Ko: Chang Gung Biotechnology, Taipei; Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan
John D Young: Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan; Chang Gung Biotechnology, Taipei; Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan; Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, USA
Hsin-Chih Lai: Center for Molecular and Clinical Immunology; Department of Medical Biotechnology and Laboratory Sciences, College of Medicine; Research Center of Bacterial Pathogenesis, Chang Gung University; Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan

DOI: https://doi.org/10.4103/2319-4170.138314
Journal volume & issue: Vol. 37, no. 5
pp. 259 – 268

Abstract

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Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.

Published in Biomedical Journal

ISSN: 2319-4170 (Print); 2320-2890 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.sciencedirect.com/journal/biomedical-journal

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Abstract

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