Revista do Instituto de Medicina Tropical de São Paulo (Feb 1993)

Avaliação em camundongo da eficácia do antiveneno administrado no local da inoculação intramuscular do veneno de Crotalus durissus terrificus Evaluation in mice, of the antivenom efficacy injected at the same place of the intramuscular inoculation of the Crotalus durissus terrificus venom

  • Lindioneza Adriano Ribeiro,
  • Carla Lilian Agostini Utescher,
  • Silvia Lucia Paro Vieira,
  • Sara Fensterseifer,
  • Helena Mukuno,
  • Miguel Tanús Jorge

DOI
https://doi.org/10.1590/S0036-46651993000100004
Journal volume & issue
Vol. 35, no. 1
pp. 23 – 27

Abstract

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A eficácia do antiveneno crotálico por via intramuscular (im) no local da inoculação, também im, do veneno de Crotalus durissus terrificus foi avaliada em camundongos. Em três experimentos inocularam-se duas DLSO do veneno por via im e administrou-se o antiveneno de três formas: metade da DE50 por via intraperitoneal (ip) e metade por via im, no mesmo local, imediatamente após (1º) e 30' após (2º) a inoculação do veneno; quatro quintos de DE50 por via ip e um quinto por via im, no mesmo local e 30' após a inoculação do veneno (3º). O antiveneno ofereceu, por via ip, maior proteção aos camundongos (menor taxa de óbito em 48 horas) do que quando foi administrado, em parte, por via im, no local da inoculação do veneno (pThe efficacy of the Crotalus durissus terrificus antivenom administration by intramuscular (im) injection at the same place of the im inoculation, of the C. d. terrificus venom was evaluated in mice. In three experiments two DL50 of the venom were inoculated and the antivenom was administered in three differents ways: half of the ED50 by intraperitoneal (ip) administration and half by injection, at the same place, immediatelly after the venom inoculation and thirty minutes after the im venom inoculation; four fifth of ED50 by ip administration and one fifth by injection, at the same place and thirty minutes after the venom inoculation. The antivenom that was administred by intraperitoneal route provided a higher protection to mice (a lower death rate in a 48 hours period) than when it was administred in parts, by intramuscular injection, at the same place of the venom inoculation (p<0,05). Therefore, it is concluded that this should not be used in human beings bitten by snakes.

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