The gut microbiota–brain axis in neurological disorders
Mingming You,
Nan Chen,
Yuanyuan Yang,
Lingjun Cheng,
Hongzhang He,
Yanhua Cai,
Yating Liu,
Haiyue Liu,
Guolin Hong
Affiliations
Mingming You
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Nan Chen
Master of Public Health School of Public Health Xiamen University Xiamen China
Yuanyuan Yang
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Lingjun Cheng
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Hongzhang He
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Yanhua Cai
Master of Public Health School of Public Health Xiamen University Xiamen China
Yating Liu
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Haiyue Liu
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Guolin Hong
Xiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China
Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function through neurotransmitters, immune modulation, and metabolic pathways. Factors like diet, lifestyle, genetics, and environment shape the gut microbiota composition together. Most research have explored how gut microbiota regulates host physiology and its potential in preventing and treating neurological disorders. However, the individual heterogeneity of gut microbiota, strains playing a dominant role in neurological diseases, and the interactions of these microbial metabolites with the central/peripheral nervous systems still need exploration. This review summarizes the potential role of gut microbiota in driving neurodevelopmental disorders (autism spectrum disorder and attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's and Parkinson's disease), and mood disorders (anxiety and depression) in recent years and discusses the current clinical and preclinical gut microbe‐based interventions, including dietary intervention, probiotics, prebiotics, and fecal microbiota transplantation. It also puts forward the current insufficient research on gut microbiota in neurological disorders and provides a framework for further research on neurological disorders.
