npj Digital Medicine (Aug 2020)
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
- Gabriel A. Brat,
- Griffin M. Weber,
- Nils Gehlenborg,
- Paul Avillach,
- Nathan P. Palmer,
- Luca Chiovato,
- James Cimino,
- Lemuel R. Waitman,
- Gilbert S. Omenn,
- Alberto Malovini,
- Jason H. Moore,
- Brett K. Beaulieu-Jones,
- Valentina Tibollo,
- Shawn N. Murphy,
- Sehi L’ Yi,
- Mark S. Keller,
- Riccardo Bellazzi,
- David A. Hanauer,
- Arnaud Serret-Larmande,
- Alba Gutierrez-Sacristan,
- John J. Holmes,
- Douglas S. Bell,
- Kenneth D. Mandl,
- Robert W. Follett,
- Jeffrey G. Klann,
- Douglas A. Murad,
- Luigia Scudeller,
- Mauro Bucalo,
- Katie Kirchoff,
- Jean Craig,
- Jihad Obeid,
- Vianney Jouhet,
- Romain Griffier,
- Sebastien Cossin,
- Bertrand Moal,
- Lav P. Patel,
- Antonio Bellasi,
- Hans U. Prokosch,
- Detlef Kraska,
- Piotr Sliz,
- Amelia L. M. Tan,
- Kee Yuan Ngiam,
- Alberto Zambelli,
- Danielle L. Mowery,
- Emily Schiver,
- Batsal Devkota,
- Robert L. Bradford,
- Mohamad Daniar,
- Christel Daniel,
- Vincent Benoit,
- Romain Bey,
- Nicolas Paris,
- Patricia Serre,
- Nina Orlova,
- Julien Dubiel,
- Martin Hilka,
- Anne Sophie Jannot,
- Stephane Breant,
- Judith Leblanc,
- Nicolas Griffon,
- Anita Burgun,
- Melodie Bernaux,
- Arnaud Sandrin,
- Elisa Salamanca,
- Sylvie Cormont,
- Thomas Ganslandt,
- Tobias Gradinger,
- Julien Champ,
- Martin Boeker,
- Patricia Martel,
- Loic Esteve,
- Alexandre Gramfort,
- Olivier Grisel,
- Damien Leprovost,
- Thomas Moreau,
- Gael Varoquaux,
- Jill-Jênn Vie,
- Demian Wassermann,
- Arthur Mensch,
- Charlotte Caucheteux,
- Christian Haverkamp,
- Guillaume Lemaitre,
- Silvano Bosari,
- Ian D. Krantz,
- Andrew South,
- Tianxi Cai,
- Isaac S. Kohane
Affiliations
- Gabriel A. Brat
- Department of Biomedical Informatics, Harvard Medical School
- Griffin M. Weber
- Department of Biomedical Informatics, Harvard Medical School
- Nils Gehlenborg
- Department of Biomedical Informatics, Harvard Medical School
- Paul Avillach
- Department of Biomedical Informatics, Harvard Medical School
- Nathan P. Palmer
- Department of Biomedical Informatics, Harvard Medical School
- Luca Chiovato
- IRCCS ICS Maugeri
- James Cimino
- UAB Informatics Institute
- Lemuel R. Waitman
- Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center
- Gilbert S. Omenn
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Alberto Malovini
- IRCCS ICS Maugeri
- Jason H. Moore
- Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine
- Brett K. Beaulieu-Jones
- Department of Biomedical Informatics, Harvard Medical School
- Valentina Tibollo
- IRCCS ICS Maugeri
- Shawn N. Murphy
- Department of Neurology, Massachusetts General Hospital
- Sehi L’ Yi
- Department of Biomedical Informatics, Harvard Medical School
- Mark S. Keller
- Department of Biomedical Informatics, Harvard Medical School
- Riccardo Bellazzi
- IRCCS ICS Maugeri
- David A. Hanauer
- Department of Pediatrics, University of Michigan Medical School
- Arnaud Serret-Larmande
- Department of Biomedical Informatics, Harvard Medical School
- Alba Gutierrez-Sacristan
- Department of Biomedical Informatics, Harvard Medical School
- John J. Holmes
- Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine
- Douglas S. Bell
- Department of Medicine, David Geffen School of Medicine at UCLA
- Kenneth D. Mandl
- Computational Health Informatics Program, Boston Children’s Hospital
- Robert W. Follett
- Department of Medicine, David Geffen School of Medicine at UCLA
- Jeffrey G. Klann
- Department of Medicine, Massachusetts General Hospital
- Douglas A. Murad
- Department of Medicine, David Geffen School of Medicine at UCLA
- Luigia Scudeller
- Scientific Direction, IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano
- Mauro Bucalo
- BIOMERIS (BIOMedical Research Informatics Solutions)
- Katie Kirchoff
- Biomedical Informatics Center, Medical University of South Carolina
- Jean Craig
- Biomedical Informatics Center, Medical University of South Carolina
- Jihad Obeid
- Biomedical Informatics Center, Medical University of South Carolina
- Vianney Jouhet
- Bordeaux University Hospital
- Romain Griffier
- Bordeaux University Hospital
- Sebastien Cossin
- Bordeaux University Hospital
- Bertrand Moal
- Bordeaux University Hospital
- Lav P. Patel
- Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center
- Antonio Bellasi
- UOC Ricerca, Innovazione e Brand Reputation, ASST Papa Giovanni XXIII
- Hans U. Prokosch
- Department of Medical Informatics, University of Erlangen-Nürnberg
- Detlef Kraska
- Center for Medical Information and Communication Technology, University Hospital Erlangen
- Piotr Sliz
- Computational Health Informatics Program, Boston Children’s Hospital
- Amelia L. M. Tan
- Department of Biomedical Informatics, Harvard Medical School
- Kee Yuan Ngiam
- National University Health Systems
- Alberto Zambelli
- Department of Oncology, ASST Papa Giovanni XXIII
- Danielle L. Mowery
- Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine
- Emily Schiver
- Penn Medicine, Data Analytics Center
- Batsal Devkota
- Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia
- Robert L. Bradford
- North Carolina Translational and Clinical Sciences (NC TraCS) Institute, UNC Chapel Hill
- Mohamad Daniar
- Computational Health Informatics Program, Boston Children’s Hospital
- Christel Daniel
- WIND Department APHP Greater Paris University Hospital
- Vincent Benoit
- WIND Department APHP Greater Paris University Hospital
- Romain Bey
- WIND Department APHP Greater Paris University Hospital
- Nicolas Paris
- WIND Department APHP Greater Paris University Hospital
- Patricia Serre
- WIND Department APHP Greater Paris University Hospital
- Nina Orlova
- WIND Department APHP Greater Paris University Hospital
- Julien Dubiel
- WIND Department APHP Greater Paris University Hospital
- Martin Hilka
- WIND Department APHP Greater Paris University Hospital
- Anne Sophie Jannot
- Department of Biomedical Informatics, HEGP, APHP Greater Paris University Hospital
- Stephane Breant
- WIND Department APHP Greater Paris University Hospital
- Judith Leblanc
- Clinical Research Unit, Saint Antoine Hospital, APHP Greater Paris University Hospital
- Nicolas Griffon
- WIND Department APHP Greater Paris University Hospital
- Anita Burgun
- Department of Biomedical Informatics, HEGP, APHP Greater Paris University Hospital
- Melodie Bernaux
- Strategy and Transformation Department, APHP Greater Paris University Hospital
- Arnaud Sandrin
- WIND Department APHP Greater Paris University Hospital
- Elisa Salamanca
- WIND Department APHP Greater Paris University Hospital
- Sylvie Cormont
- WIND Department APHP Greater Paris University Hospital
- Thomas Ganslandt
- Heinrich-Lanz-Center for Digital Health, University Medicine Mannheim, Heidelberg University
- Tobias Gradinger
- Heinrich-Lanz-Center for Digital Health, University Medicine Mannheim, Heidelberg University
- Julien Champ
- INRIA Sophia-Antipolis—ZENITH Team, LIRMM
- Martin Boeker
- Institute of Medical Biometry and Statistics, Medical Center, University of Freiburg
- Patricia Martel
- Clinical Research Unit, Paris Saclay, APHP Greater Paris University Hospital
- Loic Esteve
- SED/SIERRA, Inria Centre de Paris
- Alexandre Gramfort
- Université Paris-Saclay, Inria, CEA
- Olivier Grisel
- Université Paris-Saclay, Inria, CEA
- Damien Leprovost
- Clevy.io
- Thomas Moreau
- Université Paris-Saclay, Inria, CEA
- Gael Varoquaux
- Université Paris-Saclay, Inria, CEA
- Jill-Jênn Vie
- SequeL, Inria Lille
- Demian Wassermann
- Université Paris-Saclay, Inria, CEA
- Arthur Mensch
- ENS, PSL University
- Charlotte Caucheteux
- Université Paris-Saclay, Inria, CEA
- Christian Haverkamp
- Institute of Digitalization in Medicine, Faculty of Medicine and Medical Center, University of Freiburg
- Guillaume Lemaitre
- Université Paris-Saclay, Inria, CEA
- Silvano Bosari
- IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano
- Ian D. Krantz
- Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia
- Andrew South
- Brenner Children’s Hospital, Wake Forest School of Medicine
- Tianxi Cai
- Department of Biomedical Informatics, Harvard Medical School
- Isaac S. Kohane
- Department of Biomedical Informatics, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41746-020-00308-0
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 9
Abstract
Abstract We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries ( www.covidclinical.net ). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.
