Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

Morito Takano; Soya Kawabata; Shinsuke Shibata; Akimasa Yasuda; Satoshi Nori; Osahiko Tsuji; Narihito Nagoshi; Akio Iwanami; Hayao Ebise; Keisuke Horiuchi; Hideyuki Okano; Masaya Nakamura

doi:10.1016/j.stemcr.2017.01.013

Stem Cell Reports (Mar 2017)

Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

Morito Takano,
Soya Kawabata,
Shinsuke Shibata,
Akimasa Yasuda,
Satoshi Nori,
Osahiko Tsuji,
Narihito Nagoshi,
Akio Iwanami,
Hayao Ebise,
Keisuke Horiuchi,
Hideyuki Okano,
Masaya Nakamura

Affiliations

Morito Takano: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Soya Kawabata: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Shinsuke Shibata: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Akimasa Yasuda: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Satoshi Nori: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Osahiko Tsuji: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Narihito Nagoshi: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Akio Iwanami: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Hayao Ebise: Genomic Science Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 2-6-8 Doshoumachi, Chuo-ku, Osaka 541-0045, Japan
Keisuke Horiuchi: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Hideyuki Okano: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Masaya Nakamura: Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

DOI: https://doi.org/10.1016/j.stemcr.2017.01.013
Journal volume & issue: Vol. 8, no. 3
pp. 509 – 518

Abstract

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The number of elderly patients with spinal cord injury (SCI) is increasing worldwide, representing a serious burden for both the affected patients and the community. Previous studies have demonstrated that neural stem cell (NSC) transplantation is an effective treatment for SCI in young animals. Here we show that NSC transplantation is as effective in aged mice as it is in young mice, even though aged mice exhibit more severe neurological deficits after SCI. NSCs grafted into aged mice exhibited better survival than those grafted into young mice. Furthermore, we show that the neurotrophic factor HGF plays a key role in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI. The unexpected results of the present study suggest that NSC transplantation is a potential therapeutic modality for SCI, even in elderly patients.

Published in Stem Cell Reports

ISSN: 2213-6711 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.cell.com/stem-cell-reports/home

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