Case Reports in Gastrointestinal Medicine (Jan 2021)

Management of Refractory Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia with Bevacizumab

  • Muaaz Masood,
  • Michael Coles,
  • Humberto Sifuentes

DOI
https://doi.org/10.1155/2021/2242178
Journal volume & issue
Vol. 2021

Abstract

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Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder resulting in vascular malformations of several organs including the pulmonary, cerebral, and gastrointestinal systems. One sequela is recurrent gastrointestinal (GI) bleeding. Bevacizumab (Bev) is emerging as an effective treatment of recurrent gastrointestinal bleeding in HHT. Bev is a recombinant monoclonal antibody that inhibits vascular endothelial growth factor (VEGF), an integral part of angiogenesis.