Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS

Viviana Carmen Ciucă; Victor Viorel Safta; Carmen Otilia Rusănescu; Gigel Paraschiv; György Deák; Mihaela Ilie; Sorin Cănănău

doi:10.3390/molecules28176227

Molecules (Aug 2023)

Rapid Environmental Impact Assessment of Penicillin G in a Veterinary Product Using an Original Software Method and Monitoring by SPE-Online-UHPLC-MS/MS

Viviana Carmen Ciucă,
Victor Viorel Safta,
Carmen Otilia Rusănescu,
Gigel Paraschiv,
György Deák,
Mihaela Ilie,
Sorin Cănănău

Affiliations

Viviana Carmen Ciucă: Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
Victor Viorel Safta: Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
Carmen Otilia Rusănescu: Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
Gigel Paraschiv: Faculty of Biotechnical Systems Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania
György Deák: National Institute for Research and Development in Environmental Protection, 294 Spl. Independentei, District 6, 060031 Bucharest, Romania
Mihaela Ilie: National Institute for Research and Development in Environmental Protection, 294 Spl. Independentei, District 6, 060031 Bucharest, Romania
Sorin Cănănău: Faculty of Mechanical and Mechatronic Engineering, University of Science and Technology Politehnica Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania

DOI: https://doi.org/10.3390/molecules28176227
Journal volume & issue: Vol. 28, no. 17
p. 6227

Abstract

Read online

Veterinary antibiotics have become a major concern due to potential environmental effects. This study presents an investigation of the exposure and environmental effects of the veterinary medicinal product in powder form, administered in the drinking water of piglets, chickens and turkeys, containing 250 mg/g penicillin G (benzylpenicillin potassium), performed according to the European Medicines Agency (EMEA) guideline and the results obtained by an analytical method based on online solid-phase extraction, ultra-high performance liquid chromatography coupled to a triple quadrupole mass spectrometer (SPE-online-UHPLC-MS/MS). The study presents the determination of the environmental risk and through an original, interactive, fast software method, created on the basis of a proprietary calculation algorithm that goes through all the prescriptions and recommendations of the EMEA guide. The results demonstrated that the concentration value for penicillin G determined in surface water by SPE-online-UHPLC-MS/MS is much lower than that predicted by calculation (predictable concentration in surface water, PECsurface water = 37.66 µg/L and the concentration SPE-online-UHPLC-MS/MS = 0.032 µg/L). Both results lead to a sub-unit risk quotient (R) indicating that the treatment carried out with the considered veterinary product does not present any risk to the environment.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords