Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Oct 2022)
Prognostic Impact of Nutritional Status After Transcatheter Edge‐to‐Edge Mitral Valve Repair: The MIVNUT Registry
- Berenice Caneiro‐Queija,
- Sergio Raposeiras‐Roubin,
- Marianna Adamo,
- Xavier Freixa,
- Dabit Arzamendi,
- Tomas Benito‐González,
- Antonio Montefusco,
- Isaac Pascual,
- Luis Nombela‐Franco,
- Josep Rodes‐Cabau,
- Mony Shuvy,
- Antonio Portolés‐Hernández,
- Cosmo Godino,
- Dan Haberman,
- Laura Lupi,
- Ander Regueiro,
- Chin Hion Li,
- Felipe Fernández‐Vázquez,
- Simone Frea,
- Pablo Avanzas,
- Gabriela Tirado‐Conte,
- Jean‐Michel Paradis,
- Alona Peretz,
- Vanessa Moñivas,
- Jose A. Baz,
- Michele Galasso,
- Luca Branca,
- Laura Sanchís,
- Lluís Asmarats,
- Carmen Garrote‐Coloma,
- Filippo Angelini,
- Victor León,
- José A. de Agustín,
- Alberto Alperi,
- Ronen Beeri,
- Gloria Maccagni,
- Manel Sabaté,
- Estefanía Fernández‐Peregrina,
- Javier Gualis,
- Pier Paolo Bocchino,
- Salvatore Curello,
- Andrés Íñiguez‐Romo,
- Rodrigo Estévez‐Loureiro
Affiliations
- Berenice Caneiro‐Queija
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- Sergio Raposeiras‐Roubin
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- Marianna Adamo
- Cardiac Catheteterization Laboratory, Cardiothoracic Department, Spedali Civili Brescia Brescia Italy
- Xavier Freixa
- Hospital Clinic Barcelona Spain
- Dabit Arzamendi
- Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu Barcelona Spain
- Tomas Benito‐González
- Complejo Asistencial Universitario de León León Spain
- Antonio Montefusco
- Division of Cardiology, Department of Medical Science University of Turin Città della Salute e Della Scienza Torino Italy
- Isaac Pascual
- Interventional Cardiology Unit, Hospital Universitario Central de Asturias Oviedo Spain
- Luis Nombela‐Franco
- Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC Madrid Spain
- Josep Rodes‐Cabau
- Cardiology Department, Quebec Heart and Lung Institute Laval University Quebec City Canada
- Mony Shuvy
- Heart Institute Hadassah‐Hebrew University Medical Center Jerusalem Israel
- Antonio Portolés‐Hernández
- Cardiology Department Hospital Universitario Puerta de Hierro Madrid Spain
- Cosmo Godino
- Clinical Cardiology Unit, Faculty of Medicine IRCCS San Raffaele Scientific Institute Milan Italy
- Dan Haberman
- Kaplan Medical Center Rehovot Israel
- Laura Lupi
- Cardiac Catheteterization Laboratory, Cardiothoracic Department, Spedali Civili Brescia Brescia Italy
- Ander Regueiro
- Hospital Clinic Barcelona Spain
- Chin Hion Li
- Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu Barcelona Spain
- Felipe Fernández‐Vázquez
- Complejo Asistencial Universitario de León León Spain
- Simone Frea
- Division of Cardiology, Department of Medical Science University of Turin Città della Salute e Della Scienza Torino Italy
- Pablo Avanzas
- Interventional Cardiology Unit, Hospital Universitario Central de Asturias Oviedo Spain
- Gabriela Tirado‐Conte
- Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC Madrid Spain
- Jean‐Michel Paradis
- Cardiology Department, Quebec Heart and Lung Institute Laval University Quebec City Canada
- Alona Peretz
- Heart Institute Hadassah‐Hebrew University Medical Center Jerusalem Israel
- Vanessa Moñivas
- Cardiology Department Hospital Universitario Puerta de Hierro Madrid Spain
- Jose A. Baz
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- Michele Galasso
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- Luca Branca
- Cardiac Catheteterization Laboratory, Cardiothoracic Department, Spedali Civili Brescia Brescia Italy
- Laura Sanchís
- Hospital Clinic Barcelona Spain
- Lluís Asmarats
- Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu Barcelona Spain
- Carmen Garrote‐Coloma
- Complejo Asistencial Universitario de León León Spain
- Filippo Angelini
- Division of Cardiology, Department of Medical Science University of Turin Città della Salute e Della Scienza Torino Italy
- Victor León
- Interventional Cardiology Unit, Hospital Universitario Central de Asturias Oviedo Spain
- José A. de Agustín
- Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC Madrid Spain
- Alberto Alperi
- Cardiology Department, Quebec Heart and Lung Institute Laval University Quebec City Canada
- Ronen Beeri
- Heart Institute Hadassah‐Hebrew University Medical Center Jerusalem Israel
- Gloria Maccagni
- Cardiac Catheteterization Laboratory, Cardiothoracic Department, Spedali Civili Brescia Brescia Italy
- Manel Sabaté
- Hospital Clinic Barcelona Spain
- Estefanía Fernández‐Peregrina
- Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu Barcelona Spain
- Javier Gualis
- Complejo Asistencial Universitario de León León Spain
- Pier Paolo Bocchino
- Division of Cardiology, Department of Medical Science University of Turin Città della Salute e Della Scienza Torino Italy
- Salvatore Curello
- Cardiac Catheteterization Laboratory, Cardiothoracic Department, Spedali Civili Brescia Brescia Italy
- Andrés Íñiguez‐Romo
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- Rodrigo Estévez‐Loureiro
- Hospital Álvaro Cunqueiro and Instituto de Investigación Sanitaria Galicia Sur Vigo Spain
- DOI
- https://doi.org/10.1161/JAHA.121.023121
- Journal volume & issue
-
Vol. 11,
no. 20
Abstract
Background Malnutrition is associated with poor prognosis in several cardiovascular diseases. However, its prognostic impact in patients undergoing transcatheter edge‐to‐edge mitral valve repair (TEER) is not well known. This study sought to assess the prevalence, clinical associations, and prognostic consequences of malnutrition in patients undergoing TEER. Methods and Results A total of 892 patients undergoing TEER from the international MIVNUT (Mitral Valve Repair and Nutritional Status) registry were studied. Malnutrition status was assessed with the Controlling Nutritional Status score. The association of nutritional status with mortality was analyzed with multivariable Cox regression models, whereas the association with heart failure admission was assessed by Fine‐Gray models, with death as a competing risk. According to the Controlling Nutritional Status score, 74.4% of patients with TEER had any degree of malnutrition at the time of TEER (75.1% in patients with body mass index <25 kg/m2, 72.1% in those with body mass index ≥25 kg/m2). However, only 20% had moderate–severe malnutrition. TEER was successful in most of patients (94.2%). During a median follow‐up of 1.6 years (interquartile range, 0.6–3.0), 267 (29.9%) patients died and 256 patients (28.7%) were admitted for heart failure after TEER. Compared with normal nutritional status moderate–severe malnutrition resulted a strong predictor of mortality (adjusted hazard ratio [HR], 2.1 [95% CI, 1.1–2.4]; P<0.001) and heart failure admission (adjusted subdistribution HR, 1.6 [95% CI, 1.1–2.4]; P=0.015). Conclusions Malnutrition is common among patients submitted to TEER, and moderate–severe malnutrition is strongly associated with increased mortality and heart failure readmission. Assessment of nutritional status in these patients may help to improve risk stratification.
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