Nature Communications (Dec 2022)

Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling

  • David E. Lee,
  • Lauren K. McKay,
  • Akshay Bareja,
  • Yongwu Li,
  • Alastair Khodabukus,
  • Nenad Bursac,
  • Gregory A. Taylor,
  • Gurpreet S. Baht,
  • James P. White

DOI
https://doi.org/10.1038/s41467-022-35390-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Lee et al. demonstrate the protein Meteorin-like can rejuvenate the body’s immune system to enhance muscle regeneration in old age – in part by inducing the death of pro-fibrotic mesenchymal progenitor cells within the muscle.