Nature Communications (Mar 2021)

Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure

  • Mallory Paynich Murray,
  • Isaac Engel,
  • Grégory Seumois,
  • Sara Herrera-De la Mata,
  • Sandy Lucette Rosales,
  • Ashu Sethi,
  • Ashmitaa Logandha Ramamoorthy Premlal,
  • Goo-Young Seo,
  • Jason Greenbaum,
  • Pandurangan Vijayanand,
  • James P. Scott-Browne,
  • Mitchell Kronenberg

DOI
https://doi.org/10.1038/s41467-021-21574-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and after antigenic stimulation.