Hepatocytes prepare the soil for liver metastasis

Abstract

The liver is the most common organ site of cancer metastasis. Molecular determinants of this organotropism, though, are poorly understood. We recently showed that hepatocytes regulate the formation of a “pro-metastatic” niche in the liver via their release of serum amyloid proteins.

Keywords

• metastasis
• liver
• therapy
• pancreatic cancer
• hepatocytes