Compounds (Oct 2024)

Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine

  • Partha Sarathi Bera,
  • Yafia Kousin Mirza,
  • Tarunika Sachdeva,
  • Milan Bera

DOI
https://doi.org/10.3390/compounds4040038
Journal volume & issue
Vol. 4, no. 4
pp. 626 – 649

Abstract

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The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added molecular entities. Therefore, regioselective ring-opening reactions of aziridines with various heteroatomic nucleophiles and carbon nucleophiles establish a useful synthetic methodology to synthesize biologically relevant β-functionalized alkylamines. The regio-selective ring-opening of aziridines is highly dependent on the substrate combination, and stereochemical control is challenging for Lewis acid-promoted reactions. Therefore, the development of a robust, catalytic ring-opening process that assists in the accurate prediction of regioselectivity and stereochemistry is highly desirable. Consequently, a large number of publications detailing distinct methods for aziridine ring-opening reactions can be found in the literature. In this review, we discuss several transition metal catalyzed cross-coupling reaction protocols for the ring opening of substituted aziridines with various carbon nucleophiles.

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