Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice

Huanqing Gao; Liang Zhou; Yiming Zhong; Zhen Ding; Sixiong Lin; Xiaoting Hou; Xiaoqian Zhou; Jie Shao; Fan Yang; Xuenong Zou; Huiling Cao; Guozhi Xiao

doi:10.1038/s41467-022-28692-z

Nature Communications (Feb 2022)

Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice

Huanqing Gao,
Liang Zhou,
Yiming Zhong,
Zhen Ding,
Sixiong Lin,
Xiaoting Hou,
Xiaoqian Zhou,
Jie Shao,
Fan Yang,
Xuenong Zou,
Huiling Cao,
Guozhi Xiao

Affiliations

Huanqing Gao: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Liang Zhou: Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center
Yiming Zhong: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Zhen Ding: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Sixiong Lin: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Xiaoting Hou: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Xiaoqian Zhou: Department of Gastroenterology, The First People’s Hospital of Guiyang
Jie Shao: Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)
Fan Yang: Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)
Xuenong Zou: Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University
Huiling Cao: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Guozhi Xiao: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-28692-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Here, the authors show that expression of kindlin-2 is increased in patients with nonalcoholic fatty liver disease (NAFLD). In mouse models, specific deletion of kindlin-2 in liver ameliorates, while its overexpression exacerbates, NAFLD by modulating Foxo1 in hepatocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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