Eph-ephrin signaling in nervous system development [version 1; referees: 2 approved]

Abstract

Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.

Keywords

• Cell Adhesion
• Cell Signaling
• Chemical Biology of the Cell
• Developmental Molecular Mechanisms
• Membranes & Sorting
• Neurobiology of Disease & Regeneration
• Neurodevelopment
• Neuronal & Glial Cell Biology
• Neuronal Signaling Mechanisms
• Sensory Systems