Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design

• Ikuo Fujimori,
• Takeshi Wakabayashi,
• Morio Murakami,
• Atsutoshi Okabe,
• Tsuyoshi Ishii,
• Aaron McGrath,
• Hua Zou,
• Kumar Singh Saikatendu,
• Hiroshi Imoto

Affiliations

Ikuo Fujimori

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Takeshi Wakabayashi

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Morio Murakami

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Atsutoshi Okabe

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Tsuyoshi Ishii

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Aaron McGrath

Takeda California, Inc., San Diego, California, United States

Hua Zou

Takeda California, Inc., San Diego, California, United States

Kumar Singh Saikatendu

Takeda California, Inc., San Diego, California, United States

Hiroshi Imoto

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan