Frontiers in Aging Neuroscience (Jul 2021)
The Effect of Preoperative Antiplatelet Therapy on Early Postoperative Rehemorrhage and Outcomes in Patients With Spontaneous Intracranial Hematoma
- Junhua Yang,
- Junhua Yang,
- Junhua Yang,
- Junhua Yang,
- Qingyuan Liu,
- Qingyuan Liu,
- Qingyuan Liu,
- Qingyuan Liu,
- Shaohua Mo,
- Shaohua Mo,
- Shaohua Mo,
- Shaohua Mo,
- Kaiwen Wang,
- Kaiwen Wang,
- Kaiwen Wang,
- Kaiwen Wang,
- Maogui Li,
- Maogui Li,
- Maogui Li,
- Maogui Li,
- Jun Wu,
- Jun Wu,
- Jun Wu,
- Jun Wu,
- Pengjun Jiang,
- Pengjun Jiang,
- Pengjun Jiang,
- Pengjun Jiang,
- Shuzhe Yang,
- Shuzhe Yang,
- Shuzhe Yang,
- Shuzhe Yang,
- Rui Guo,
- Rui Guo,
- Rui Guo,
- Rui Guo,
- Yi Yang,
- Yi Yang,
- Yi Yang,
- Yi Yang,
- Jiaming Zhang,
- Jiaming Zhang,
- Jiaming Zhang,
- Jiaming Zhang,
- Yang Liu,
- Yang Liu,
- Yang Liu,
- Yang Liu,
- Yong Cao,
- Yong Cao,
- Yong Cao,
- Yong Cao,
- Shuo Wang,
- Shuo Wang,
- Shuo Wang,
- Shuo Wang
Affiliations
- Junhua Yang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Junhua Yang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Junhua Yang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Junhua Yang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Qingyuan Liu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Qingyuan Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Qingyuan Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Qingyuan Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Shaohua Mo
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Shaohua Mo
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Shaohua Mo
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Shaohua Mo
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Kaiwen Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Kaiwen Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Kaiwen Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Kaiwen Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Maogui Li
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Maogui Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Maogui Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Maogui Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jun Wu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jun Wu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jun Wu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jun Wu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Pengjun Jiang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Pengjun Jiang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Pengjun Jiang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Pengjun Jiang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Shuzhe Yang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Shuzhe Yang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Shuzhe Yang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Shuzhe Yang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Rui Guo
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Rui Guo
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Rui Guo
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Rui Guo
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yi Yang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yi Yang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yi Yang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yi Yang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jiaming Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jiaming Zhang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jiaming Zhang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jiaming Zhang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yang Liu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yang Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yang Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yang Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yong Cao
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yong Cao
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yong Cao
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yong Cao
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Shuo Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Shuo Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Shuo Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Shuo Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- DOI
- https://doi.org/10.3389/fnagi.2021.681998
- Journal volume & issue
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Vol. 13
Abstract
Background and PurposeThe effect of antiplatelet therapy (APT) on early postoperative rehemorrhage and outcomes of patients with spontaneous intracerebral hemorrhage (ICH) is still unclear. This study is to evaluate the effect of preoperative APT on early postoperative rehemorrhage and outcomes in ICH patients.MethodsThis was a multicenter cohort study. ICH patients undergoing surgery were divided into APT group and no antiplatelet therapy (nAPT) group according to whether patients received APT or not. Chi-square test, t-test, and Mann–Whitney U test were used to compare the differences in variables, postoperative rehematoma, and outcomes between groups. Multivariate logistics regression analysis was used to correct for confounding variables, which were different in group comparison.ResultsOne hundred fifty ICH patients undergoing surgical treatment were consecutively included in this study. Thirty five (23.33%) people were included in the APT group, while 115 (76.67%) people were included in the nAPT group. The incidence of early postoperative rehemorrhage in the APT group was significantly higher than that in the nAPT group (25.7% VS 10.4%, p = 0.047 < 0.05). After adjustment for age, ischemic stroke history, and ventricular hematoma, preoperative APT had no significant effect on early postoperative rehemorrhage (p = 0.067). There was no statistical difference between the two groups in early poorer outcomes (p = 0.222) at 14 days after surgery. After adjustment for age, ischemic stroke history, and ventricular hematoma, preoperative APT also had no significant effect on early poorer modified Rankin Scale (mRS) (p = 0.072).ConclusionIn conclusion, preoperative APT appears to be safe and have no significant effect on early postoperative rehematoma and outcomes in ICH patients.
Keywords