PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans

Jieyu Wu; Xue Jiang; Yamei Li; Tingting Zhu; Jingjing Zhang; Zhiguo Zhang; Linqiang Zhang; Yuru Zhang; Yanli Wang; Xiaoju Zou; Bin Liang

doi:10.1038/s41467-018-03531-2

Nature Communications (Mar 2018)

PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans

Jieyu Wu,
Xue Jiang,
Yamei Li,
Tingting Zhu,
Jingjing Zhang,
Zhiguo Zhang,
Linqiang Zhang,
Yuru Zhang,
Yanli Wang,
Xiaoju Zou,
Bin Liang

Affiliations

Jieyu Wu: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Xue Jiang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Yamei Li: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Tingting Zhu: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Jingjing Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Zhiguo Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Linqiang Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Yuru Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Yanli Wang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences
Xiaoju Zou: Key Laboratory of Special Biological Resource Development and Utilization of University in Yunnan Province, Department of Life Science and Biotechnology, Kunming University
Bin Liang: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Center for Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-03531-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genes

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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