Nature Communications (Mar 2019)

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

  • Bing Zhao,
  • Ying Chen,
  • Ning Jiang,
  • Li Yang,
  • Shenfei Sun,
  • Yan Zhang,
  • Zengqi Wen,
  • Lorraine Ray,
  • Han Liu,
  • Guoli Hou,
  • Xinhua Lin

DOI
https://doi.org/10.1038/s41467-019-09060-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem cell fate.