The last years have been marked by the attempts to approach the management discipline from a new, innovative perspective, in accordance with the present times, marked by complex challenges and highly increased competition. Given the importance and impact of scientific advances and also the explosion of research in the field of neuroscience, management had to be redefined and its critical variables had to be analyzed from a different perspective. An interdisciplinary vision was needed to enable future researches and explanations of the decision-making processes, leadership practices, change management, innovation, creativity, human resources performance, engagement of people and emotions. Literature review has been made, from the classical management theories and models, the historical concepts of man, to the new, full of perspectives spectrum of neuroscience, brain functioning and, its infinite potential, that opened new horizons, uncovered resources and tools to face the realities of the new business world. The main purpose of this article is to overview the transition from management to neuromanagement, from leadership to neuroleadership, the role and impact of these concepts on the holistic approach of management science. This evolution allows not only the confirmation of a set of assumptions but also access to a wide range of knowledge, with multiple possibilities of applications in organizational management and opens avenues for future researches.