P-116 PREGNANCY AFTER LIVER TRANSPLANTATION: OUTCOMES IN PERU

Abstract

Introduction: Pregnancy after liver transplantation has favorable results, but maternal and graft risk, optimal immunosuppression (IS), and fetal outcomes are described. Objective: To show our outcomes of pregnancy after liver transplantation Materials and Methods: This is a case series study. We conducted a retrospective review of liver transplant recipients who had received prenatal care at Guillermo Almenara Hospital between Mach 2001 and February 2021 Results: During the study period, 286 patients underwent liver transplantation. There were 45 women (15 %) in childbearing age (15-45 years old), and 7 (15%) of them became pregnant during the study period.There was a total of 7 pregnancies. The mean age of patients at the time of transplant was 31.7 +- 4.5 years, and the mean interval between transplant and conception were 16.6 (IQR 38, 25 % <11.6 meses). There were 5 live births (71.4%), 1 spontaneous miscarriage (14 %), and one fetal death at 22 weeks. Median gestational age at delivery was 34.8+-4.21 weeks (range, 29–39), and the median birthweight was 2483 g (range, 1350–3060 g). Prematurity occurred in 3 (60 %) neonates, and 3 (60 %) neonates were adequate birth weight. Apgar scores were ≥7 in 100 %.All the pregnant has an immunosuppressive regimen base in tacrolimus. One pregnant with chronic rejection had a newborn with good evolution. Conclusions: The Pregnancy after liver transplantation had a favorable outcome in most of our cases, but there are still serious risks to the mother and the fetus. The Evaluation and follow-up must involve a multidisciplinary team.

Keywords

• LIVER TRANSPLANT
• PREGNANCY
• TACROLIMUS