Nature Communications (Sep 2021)

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

  • Robin Schmitz,
  • Zachary W. Fitch,
  • Paul M. Schroder,
  • Ashley Y. Choi,
  • Miriam Manook,
  • Janghoon Yoon,
  • Mingqing Song,
  • John S. Yi,
  • Sanjay Khandelwal,
  • Gowthami M. Arepally,
  • Alton B. Farris,
  • Edimara S. Reis,
  • John D. Lambris,
  • Jean Kwun,
  • Stuart J. Knechtle

DOI
https://doi.org/10.1038/s41467-021-25745-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.