A bioabsorbable mechanoelectric fiber as electrical stimulation suture

Zhouquan Sun; Yuefan Jin; Jiabei Luo; Linpeng Li; Yue Ding; Yu Luo; Yan Qi; Yaogang Li; Qinghong Zhang; Kerui Li; Haibo Shi; Shankai Yin; Hongzhi Wang; Hui Wang; Chengyi Hou

doi:10.1038/s41467-024-52354-x

Nature Communications (Oct 2024)

A bioabsorbable mechanoelectric fiber as electrical stimulation suture

Zhouquan Sun,
Yuefan Jin,
Jiabei Luo,
Linpeng Li,
Yue Ding,
Yu Luo,
Yan Qi,
Yaogang Li,
Qinghong Zhang,
Kerui Li,
Haibo Shi,
Shankai Yin,
Hongzhi Wang,
Hui Wang,
Chengyi Hou

Affiliations

Zhouquan Sun: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Yuefan Jin: Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Jiabei Luo: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Linpeng Li: Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Yue Ding: Department of General Surgery, Tongji Hospital, Tongji University Medical School
Yu Luo: Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering Shanghai University of Engineering Science
Yan Qi: Yangzhi Rehabilitation Hospital Affiliated to Tongji University, Tongji University School of Medicine
Yaogang Li: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Qinghong Zhang: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Kerui Li: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Haibo Shi: Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shankai Yin: Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Hongzhi Wang: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University
Hui Wang: Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai JiaoTong University, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Chengyi Hou: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University

DOI: https://doi.org/10.1038/s41467-024-52354-x
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 12

Abstract

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Abstract In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation is a non-pharmacological therapy that promotes wound healing. In this context, we designed a passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed of (poly(lactic-co-glycolic acid), polycaprolactone) and magnesium to allow safe degradation. In addition to the excellent mechanical properties, the mechanoelectrical nature of the suture grants the generation of electric fields in response to movement and stretching. This is shown to speed up wound healing by 50% and reduce the risk of infection. This work presents an evolution of the conventional wound closure procedures, using a safe and degradable device ready to be translated into clinical practice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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