Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Abstract

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G11 and Go, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.