NeuroImage (Jul 2022)
Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity
- Jorge Bosch-Bayard,
- Fuleah Abdul Razzaq,
- Carlos Lopez-Naranjo,
- Ying Wang,
- Min Li,
- Lidice Galan-Garcia,
- Ana Calzada-Reyes,
- Trinidad Virues-Alba,
- Arielle G. Rabinowitz,
- Carlos Suarez-Murias,
- Yanbo Guo,
- Manuel Sanchez-Castillo,
- Kassandra Roger,
- Anne Gallagher,
- Leslie Prichep,
- Simon G. Anderson,
- Christoph M. Michel,
- Alan C. Evans,
- Maria L. Bringas-Vega,
- Janina R. Galler,
- Pedro A. Valdes-Sosa
Affiliations
- Jorge Bosch-Bayard
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada
- Fuleah Abdul Razzaq
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
- Carlos Lopez-Naranjo
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
- Ying Wang
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
- Min Li
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
- Lidice Galan-Garcia
- Cuban Neuroscience Center, La Habana, Cuba
- Ana Calzada-Reyes
- Cuban Neuroscience Center, La Habana, Cuba
- Trinidad Virues-Alba
- Cuban Neuroscience Center, La Habana, Cuba
- Arielle G. Rabinowitz
- Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
- Carlos Suarez-Murias
- Cuban Neuroscience Center, La Habana, Cuba
- Yanbo Guo
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
- Manuel Sanchez-Castillo
- Cuban Neuroscience Center, La Habana, Cuba
- Kassandra Roger
- LION Lab, Sainte-Justine University Hospital Research Centre, University of Montreal, Montreal, QC, Canada
- Anne Gallagher
- LION Lab, Sainte-Justine University Hospital Research Centre, University of Montreal, Montreal, QC, Canada
- Leslie Prichep
- Brain Research Laboratories, New York University, USA
- Simon G. Anderson
- Caribbean Institute for Health Research, University of the West Indies, Barbados
- Christoph M. Michel
- Department of Basic Neurosciences, University of Geneva, Switzerland
- Alan C. Evans
- McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada
- Maria L. Bringas-Vega
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Cuban Neuroscience Center, La Habana, Cuba; Corresponding authors.
- Janina R. Galler
- Division of Pediatric Gastroenterology and Nutrition, Mucosal Immunology and Biology Research Center, Mass General Hospital for Children, Boston, MA, USA; Corresponding authors.
- Pedro A. Valdes-Sosa
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada; Cuban Neuroscience Center, La Habana, Cuba; Corresponding authors.
- Journal volume & issue
-
Vol. 254
p. 119144
Abstract
Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5–11 years of age and 40 years later at 45–51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.
