Microbiome (Dec 2022)
The global distribution and environmental drivers of the soil antibiotic resistome
- Manuel Delgado-Baquerizo,
- Hang-Wei Hu,
- Fernando T. Maestre,
- Carlos A. Guerra,
- Nico Eisenhauer,
- David J. Eldridge,
- Yong-Guan Zhu,
- Qing-Lin Chen,
- Pankaj Trivedi,
- Shuai Du,
- Thulani P. Makhalanyane,
- Jay Prakash Verma,
- Beatriz Gozalo,
- Victoria Ochoa,
- Sergio Asensio,
- Ling Wang,
- Eli Zaady,
- Javier G. Illán,
- Christina Siebe,
- Tine Grebenc,
- Xiaobing Zhou,
- Yu-Rong Liu,
- Adebola R. Bamigboye,
- José L. Blanco-Pastor,
- Jorge Duran,
- Alexandra Rodríguez,
- Steven Mamet,
- Fernando Alfaro,
- Sebastian Abades,
- Alberto L. Teixido,
- Gabriel F. Peñaloza-Bojacá,
- Marco A. Molina-Montenegro,
- Cristian Torres-Díaz,
- Cecilia Perez,
- Antonio Gallardo,
- Laura García-Velázquez,
- Patrick E. Hayes,
- Sigrid Neuhauser,
- Ji-Zheng He
Affiliations
- Manuel Delgado-Baquerizo
- Laboratorio de Biodiversidad y Funcionamiento Ecosistémico. Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC
- Hang-Wei Hu
- Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
- Fernando T. Maestre
- Instituto Multidisciplinar para el Estudio del Medio “Ramón Margalef”, Universidad de Alicante
- Carlos A. Guerra
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- Nico Eisenhauer
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- David J. Eldridge
- Centre for Ecosystem Science, School of Biological, Earth and Environmental Sciences, University of New South Wales
- Yong-Guan Zhu
- State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
- Qing-Lin Chen
- Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
- Pankaj Trivedi
- Microbiome Network and Department of Agricultural Biology, Colorado State University
- Shuai Du
- State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
- Thulani P. Makhalanyane
- Department of Biochemistry, Genetics and Microbiology, Centre for Microbial Ecology and Genomics, University of Pretoria
- Jay Prakash Verma
- Plant-Microbe Interactions Lab., Institute of Environment and Sustainable Development, Banaras Hindu University
- Beatriz Gozalo
- Instituto Multidisciplinar para el Estudio del Medio “Ramón Margalef”, Universidad de Alicante
- Victoria Ochoa
- Instituto Multidisciplinar para el Estudio del Medio “Ramón Margalef”, Universidad de Alicante
- Sergio Asensio
- Instituto Multidisciplinar para el Estudio del Medio “Ramón Margalef”, Universidad de Alicante
- Ling Wang
- Institute of Grassland Science/School of Life Science, Northeast Normal University, and Key Laboratory of Vegetation Ecology, Ministry of Education
- Eli Zaady
- Agricultural Research Organization, Department of Natural Resources, Institute of Plant Sciences, Gilat Research Center
- Javier G. Illán
- Department of Entomology, Washington State University
- Christina Siebe
- Instituto de Geología, Universidad Nacional Autónoma de México, Ciudad Universitaria
- Tine Grebenc
- Department of Forest Physiology and Genetics, Slovenian Forestry Institute
- Xiaobing Zhou
- State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, CAS
- Yu-Rong Liu
- College of Resources and Environment, Huazhong Agricultural University
- Adebola R. Bamigboye
- Natural History Museum, Obafemi Awolowo University
- José L. Blanco-Pastor
- INRAE, UR4 (URP3F), Centre Nouvelle-Aquitaine-Poitiers
- Jorge Duran
- Misión Biolóxica de Galicia, Consejo Superior de Investigaciones Científicas
- Alexandra Rodríguez
- Department of Life Sciences, Centre for Functional Ecology, University of Coimbra
- Steven Mamet
- College of Agriculture and Bioresources Department of Soil Science, University of Saskatchewan
- Fernando Alfaro
- GEMA Center for Genomics, Ecology & Environment, Universidad Mayor
- Sebastian Abades
- GEMA Center for Genomics, Ecology & Environment, Universidad Mayor
- Alberto L. Teixido
- Departamento de Botânica e Ecologia, Instituto de Biociências, Universidade Federal de Mato Grosso
- Gabriel F. Peñaloza-Bojacá
- Laboratório de Sistemática Vegetal, Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Marco A. Molina-Montenegro
- Centro de Ecología Integrativa, ICB, Universidad de Talca
- Cristian Torres-Díaz
- Grupo de Biodiversidad y Cambio Global (BCG), Departamento de Ciencias Básicas, Universidad del Bío-Bío, Campus Fernando May
- Cecilia Perez
- Instituto de Ecología y Biodiversidad
- Antonio Gallardo
- Unidad Asociada CSIC-UPO (BioFun), Universidad Pablo de Olavide
- Laura García-Velázquez
- Departamento de Sistemas Físicos, Químicos y Naturales, Universidad Pablo de Olavide
- Patrick E. Hayes
- School of Biological Sciences, The University of Western Australia
- Sigrid Neuhauser
- Institute of Microbiology, University of Innsbruck
- Ji-Zheng He
- Faculty of Veterinary and Agricultural Sciences, The University of Melbourne
- DOI
- https://doi.org/10.1186/s40168-022-01405-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Abstract Background Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. Video Abstract
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