Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines
Kazuki Hirano,
Satoshi Gondo,
Nagender Punna,
Etsuko Tokunaga,
Prof. Dr. Norio Shibata
Affiliations
Kazuki Hirano
Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan
Satoshi Gondo
Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan
Nagender Punna
Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan
Etsuko Tokunaga
Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan
Prof. Dr. Norio Shibata
Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555 Japan
Abstract A micro‐flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro‐flow transformation of N‐sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro‐flow synthesis, the formal micro‐flow synthesis of Efavirenz is described.
